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KMID : 0370219800240010011
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Yakhak Hoeji
1980 Volume.24 No. 1 p.11 ~ p.14
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Studies on Cephalexin Prodrug(I). Availability of Cephalexin Phthalidyl Ester as a Cephalexin Prodrug
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조윤성/Chough YS
추연성/심중익/Choo YS/Yang JI
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Abstract
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In order to increase the gastrointestinal absorption of cephalexin, a new cephalexin phthalidyl ester was synthesized. Comparative studies of cephalexin and cephalexin phthalidyl ester in the gastro-intestinal absorption were conducted after oral administration in rabbits. The amounts of cephalexin in plasma were determimed by a fluorometric method. Cephalexin phthalidyl ester could not be identified in plasma, but only cephalexin was found by TLC method. In comparison with cephalexin, cephalexin phthalidyl ester produced much higher plasma levels of cephalexin than did cephalexin itself after its oral administration in rabbits.
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